Not only is man in arms against God, but God is against wicked man also. "God is angry with the wicked every day - He hath bent his bow and made it ready. He hath also prepared for him the instruments of death" (Psalm 7:11-13). God has set up His royal standard in defiance of all the sons and daughters of Adam, who are traitors to His crown. And He has taken the field as with fire and sword against everyone who rebels against His Word. God gives sufficient testimony of His wrath by revealing how He judges sinners--they are crushed to death by his righteous foot, a fate suited to their viperous master in sin.
At every door where sin enters, the anger of God meets it there. Because each faculty of the soul and member of the body is used as a weapon of unrighteousness against God, so every one, even to the tip of the tongue, receives its portion of divine wrath. And just as man is sinful all over, so he is cursed all over--inside and outside, soul and body alike. Curses and punishments are written all over him so closely together that there is not room for one more to be added to those God has already written.
In a word, the Lord's displeasure against sinful man is so fiery that all creation must share in it. Although God takes aim at man, and levels His arrows primarily at him, yet they wound other creatures as well. God's curses, then, blasts the whole creation for man's sake; and part of the misery of man is paid to him through the fallen creation, through all the forces and creation of the natural world which originally were ordained to minister to man and to provide contributing drops in the filling of his cup of joy.
We can compare God's plagues to an enraged army which spoils all the enemies' land--destroying their supplies, poisoning their water, and burning their homes. Nothing escapes the fury of it. The very bread we eat, air we breathe, and water we drink are poisoned with God's curse, so that even the oldest, healthiest living man will eventually die.